Ye Lab @ UGA Publications

Publications

* indicates co-first authors; ^ indicates co-corresponding authors; names of group members are in bold; # indicates undergraduate trainees; $ indicates high-school students;

46. Sun Y, Xu H, Ye K. Genome-wide association studies and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating polyunsaturated, monounsaturated, and saturated fatty acids. (medRxiv)

45. Lu Y, Xu H, Sun Y, Ihejirika SA, Chiang CWK, Darst BF, Song S, Shen Y, Ye K. Gene-diet interaction analysis in UK Biobank identified genetic loci that modify the association between fish oil supplementation and the incidence of dementia. (submitted, medRxiv)

44. Xu H*, Sun Y*, Francis M, Cheng CF#, Modulla NTR#, Brenna JT, Chiang CWK, Ye K. Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders. (Submitted, medRxiv)
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  1. Zhang Y, Sun Y, Song S, Khankari NK, Brenna JT, Shen Y^, Ye K^. Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: a population-based cohort study in UK Biobank. International Journal of Cancer. (2024) (medRxiv)
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  1. Yang S, Cai H, Ye K. Phenome-wide association study of population-differentiating genetic variants around gene ACSL1. Evolution, Medicine, and Public Health. (2024)
  1. Strosahl J, Ye K, Pazdro R. Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks. BMC Genomics. (2024)
  1. Yu W, Kastriti ME, Ishan M, Choudhary SK, Rashid MM, Kramer N, Do HGT#, Wang Z, Xu T, Schwabe RF, Ye K, Adameyko I, Liu HX. The duct of von Ebner’s glands is a source of Sox10+ taste bud progenitors and susceptible to pathogen infections. Frontiers in Cell and Developmental Biology. (2024)
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  1. Sun Y, McDonald T#, Baur A#, Xu H, Bateman NB#, Shen Y, Li C, Ye K. Fish oil supplementation modifies the associations between genetically predicted and observed levels of blood lipids: a cross-sectional gene-diet interaction study in UK Biobank. The American Journal of Clinical Nutrition. (2024) (medRxiv)
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  1. Francis M, Westerman KE, Manning AK, Ye K. Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. PLOS Genetics. (2024)
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  1. Zhang Y, Sun Y, Yu Q, Song S, Brenna JT, Shen Y^, Ye K^. Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank. eLife. (2024)
  1. Sun Y, Ye K. The Protective Effect of Omega-3 Fatty Acids in Attenuating Lung Function Decline. American Journal of Respiratory and Critical Care Medicine. (2023)
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  1. Ge A*$, Sun Y*, Kiker T$, Zhou Y, Ye K. A metabolome-wide Mendelian randomization study prioritizes potential causal circulating metabolites for multiple sclerosis. Journal of Neuroimmunology. (2023) (medRxiv)
  1. Kong Q, Xia S, Pan X, Ye K, …, Zhang Z. Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis. Science Immunology (2023)
  1. Zhang H, …, Zhou J, Liu L#…, Ye K, Zhang Y, Stolfi A, Bi P. Evolution of a chordate-specific mechanism for myoblast fusion. Science Advances. (2022)
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  1. Sun Y, Chatterjee R#, Ronanki A#, Ye K. Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis. Frontiers in Medicine. (2022)
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  1. Sun Y, Zhou J, Ye K. Extensive Mendelian randomization study identifies potential causal risk factors for severe COVID-19. Communications Medicine. (2021) preprint
  1. Lei MK, Beach S, Simons R, Ye K. The Impact of Harsh Parenting on the Development of Obesity in Adulthood: An Examination of Epigenetic/Gene Expression Mediators Among African American Youth. Frontiers in Cardiovascular Medicine. (2021)
  1. Wang Y, Guo X, Ye K, Orth M, Gu Z. Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington’s disease. Proceedings of the National Academy of Sciences. (2021)
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  1. Yang S, Ye K. Recent advances in understanding the adaptive evolution of metabolic genes and traits. Current Opinion in Clinical Nutrition and Metabolic Care. (2021)
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  1. Francis M, Li C, Sun Y, Zhou J, Li X, Brenna JT, Ye K. Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci. PLOS Genetics. (2021)
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  1. Sun Y, Zhou J, Ye K. White blood cells and severe COVID-19: a Mendelian randomization study. Journal of Personalized Medicine. (2021) medRxiv
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  1. Zhou J, Liu C#, Francis M, Sun Y, Ryu MS, Grider A, Ye K. Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis. Osteoarthritis and Cartilage. (2021)
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  1. Zhou J, Sun Y, Huang W, Ye K. Altered blood cell traits underlie a major genetic locus of severe COVID-19. The Journals of Gerontology: Series A (2021) medRxiv
  1. Ma Y, …, Ye K, Yin H, Cai H. Long chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation. Oncogene (2021)
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  1. Zhou J, Liu C#, Sun Y, Huang W, Ye K. Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain, Behavior, and Immunity (2020)
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  1. Zhou J, Liu C#, Francis M, Sun Y, Ryu MS, Grider A, Ye K. The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-wide Mendelian Randomization Study. Nutrients. (2020)
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  1. Wang Z, Zhou J, Marshall B, Rekaya R, Ye K, Liu H. SARS-CoV-2 receptor ACE2 is enriched in a subpopulation of mouse tongue epithelial cells in non-gustatory papillae, but not in taste buds or embryonic oral epithelium. ACS Pharmacology & Translational Science. (2020)
  1. Beach S, …, Ye K. Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated. Development and Psychopathology. (2020)
  1. Yuan M, …, Sun Y, …, Ye K, et al. zDHHC12-mediated Claudin-3 S-Palmitoylation Determines Ovarian Cancer Progression. Acta Pharmaceutica Sinica B. (2020)
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  1. Norris ET, Rishishwar L, Chande AT, Conley AB, Ye K, Valderrama-Aguirre A, Jordan IK. Admixture-enabled selection for rapid adaptive evolution in the Americas. Genome Biology. 21(1):29 (2020)
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  1. Huang L, Ye K, et al. IL-2 inducible T cell kinase (ITK) deficiency impairs early pulmonary protection against Mycobacterium tuberculosis infection. Frontiers in Immunology. doi:10.3389/fimmu.2019.03103 (2020)
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  1. Fragoza R, …, Ye K, et al. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Nature Communication. 10(1):4141 (2019)
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  1. Si Y, Liu X, Ye K, Bonfini A, Hu X, Buchon N, Gu Z. Glucomannan hydrolysate promotes gut proliferative homeostasis and extends lifespan in Drosophila melanogaster. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences doi:10.1093/gerona/gly189 (2018)
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  1. Zhang R, Wang Y, Ye K, Picard M, Gu Z. Independent impacts of aging on mitochondrial DNA quantity and quality in humans. BMC Genomics 18, 890 (2017)
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  1. Ye K, Gao F, Wang D, Bar-Yosef O, Keinan A. Dietary adaptation of FADS genes in Europe varied across time and geography. Nature Ecology and Evolution 1, 0167 (2017)
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  1. Kothapalli KSD*, Ye K*, Gadgil MS, et al. Positive selection on a regulatory insertion–deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid. Molecular Biology and Evolution 33 (7), 1726-1739 (2016)
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  1. Billing-Ross P, Germain A, Ye K, Keinan A, Gu Z, Hanson MR. Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. Journal of Translational Medicine 14 (1), 19 (2016)
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  1. Ye K*, Cao C*, Lin X, O'Brien KO, Gu Z. Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption. BMC Genetics 16 (1), 61 (2015)
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  1. Lei R, Ye K, Gu Z, Sun X. Diminishing returns in next-generation sequencing (NGS) transcriptome data. Gene 557 (1), 82-87 (2015)
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  1. Ye K^, Lu J, Ma F, Keinan A, Gu Z^. Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals. Proceedings of the National Academy of Sciences 111 (29), 10654-10659 (2014)
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  1. Ye K^, Lu J, Raj SM, Gu Z^. Human expression QTLs are enriched in signals of environmental adaptation. Genome Biology and Evolution 5 (9), 1689-1701 (2013)
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  1. Ye K and Gu Z. Recent advances in understanding the role of nutrition in human genome evolution. Advances in Nutrition 2 (6), 486-496 (2011)
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  1. Xue Z, He Y, Ye K, Gu Z, Mao Y, Qi L. A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha. Journal of Biological Chemistry 286 (35), 30859-30866 (2011)
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  1. Fang X, Zhang Y, Zhang R, Yang L, Li M, Ye K, Guo X, Wang J, Su B. Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque. Genome Biology 12, R63 (2011)
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  1. Lai J, …, Ye K, …, et al. Genome-wide patterns of genetic variation among elite maize inbred lines. Nature Genetics 42 (11), 1027-1030 (2010)
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  1. Ye K, Liu K, Zhang L. The inductive effect of ultraviolet radiation on mycosporine-like amino acids (MAAs) in Microcystis aeruginosa. Amino Acids and Biotic Resources 30 (1), 25-28 (2008)

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